Perhaps if it is possible to turn off hardware acceleration of the Windows 10 UI, this problem would go away (i.e. classing UI? Is it even available in Windows 10?). But that would negatively affect the performance and power consumption of the device. I would not take that route even if it was possible.
The solution I have for now is turning off ShadowPlay when I am not playing a game and turning it back on before I launch a game. Hopefully someone – Microsoft of NVidia – will be able to fix this soon.